Designing and Micro/nano-fabricating Portable Impedance-based Point-of-care biosensors
Companion diagnostics are central to the success of personalized medicine. The portable glucose sensor is indeed the most successful example of a companion diagnostic device. They are used by millions of diabetics worldwide to monitor their health and help make decisions about their medication usage. Building from this example, the lecturer will present the power of metabolomics to develop a collection of multiplexed companion diagnostic systems on a unified platform that can be used to diagnose, monitor, or predict multiple diseases. Metabolomics is an emerging field of “omics” science. Metabolites are very sensitive to geneenvironments or gene-pathogen interactions. In this invited talk, the lecturer will discuss their impedance-based biosensor design to measure not just one metabolite, but dozens or even hundreds at a time from human body fluids (such as blood, urine). The testing time is within 10 minutes at the cost of $1 US Dollar per metabolite test. The sensor is also able to detect metabolites at the concentration of nM. To avoid “false positive”, a competitive assay design was applied. Such a platform technology can be easily extended for environmental monitoring, food-safety checking, cancer screening and infectious disease diagnosing.
Dr. Jie Chen is currently a Professor in the Faculty of Engineering at the University of Alberta. He is also a research officer at National Research Council / National Institute for Nanotechnology. Dr. Chen is an IEEE Fellow and a Fellow of the Engineering Institute of Canada. He received the Killam Professorship Award for his outstanding contributions to research, teaching and community service. He has nearly 15 years of project, administrative and management experience and has successfully helped found two spin-off companies. One was acquired by QUALCOMM in 2005, and the other produces digital HD-radios installed in most brands of automobiles and sold in Walmart and Best Buy.